Would a mutation be more harmful in an intron or an exon? Explain.

Expert Solution

To understand this explanation we have to know about what is intron and exon?

Introns and exons are nucleotide sequences within a gene. Exons are the coding areas, whereas introns are the non- coding areas so we can say that an exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. Introns are supposed to be removed, while the exons are expressed. Mutations in introns are most harmful as mutations occur at a specific site at which introns splicing occurs. The mutation can be insertion, deletion, frameshift which is more harmful mutations.

If mutations occur in introns that mutations disrupt the signals for splicing out the introns and mutations that causes the incorrect splicing, the sequence of the mature mRNA does not code the usual protein as a result that causes disease or may have a different functions than the spliced protein. For example, mutations that cause the incorrect splicing of Beta-globin mRNA are responsible for some cases of Beta- thalassemia. But introns are non-coding sequences as they do not produce any protein after gene expression, it may produce a protein that is not expected.

gladiator answered 2 years ago

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