- The change or alteration in the structure of DNA or chromatin
in eukaryotes, including, DNA methylation, DNA Acetylation,
Chromatin structure changes, remodeling, histone modification, is
termed as epigenetics.
- Chromosome is organized form of DNA in eukaryotic cells.
- The chromatin is organized with the help of histone proteins to
form the nucleosome.
- About 146-147 bp DNA length is tightly wrapped around octameric
core histones (Two copies of each H2A, H2B, H3 and H4 histone
proteins).
- These nucleosome cores are separated by linker DNA, which are
associated with Histone H1.
- Modification of histone at the basic N-terminal amino acid
tails causes the amino acid tails to protrude out of their specific
nucleosome and interact with adjacent nucleosomes. This alters the
interaction of DNA and histone proteins, resulting in DNA to loosen
or become more tightly coiled with histone.
Ubiquination is mainly involved in DNA repair.
Answer: Ubiquination