In: Biology
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A. Oxaloacetate is very important in TCA cycle. Acetyl CoA combines with Oxaloacetate to form citric acid, This is the first step in TCA cycle. So Oxaloacetate has to be present for the TCA cycle to go on in the mitochondria. No TCA and hence ETC also can't produce sufficient ATP molecules. That is why there is lack of energy.
B. Pyruvate dehydrogenase path way is regulated by reversible modification of PDH. It is brought by various kinases. Pyruvate dehydrogenase kinase inactivates PDH by phosphorylation with ATP. It will reactivate by Pyruvate dehydrogenase phosphatase.
PDH kinase is stimulated by NADH and Acetyl CoA , where as inhibited by Pyruvate. Because the weired path way is similar to PDH, it can be regulated by using kinases similar to PDH which will inhibit the path way of Oxaloacetate.
C. Coenzyme -Q is very important because it is an important mobile carrier in electron transport chain. It carrier electrons from complex I and II to complex III. Lack of this mobile carrier will prevent ATP formation. That is why the energy is less in the twins.
D. Co enzyme Q is present int e ETC which is located in the inner mitochondrial membrane. Mostly Coenzyme Q is synthesised in the body with tyrosine. That is why by just adding foods rich in Coenzyme Q will not increase the energy levels of the twins.