How does immune system reacts to alpha- gal syndrome? explain in detail

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Galactose-alpha-1,3-galactose (alpha-gal) is a carbohydrate found in the cells of many mammals that humans eat, such as cows, sheep, and pigs. Poultry that has been injected with natural flavoring containing beef or other mammal cells may also have alpha-gal. As a result of autoimmune responses, some people become allergic to alpha-gal.

People with this allergy may experience mild discomfort after eating meat, or they may have a dangerous reaction that leaves them unable to breathe. The spectrum of reactions to alpha-gal varies. Most instances of this allergy are triggered by tick bites.

Recent research has shown that saliva from the lone star tick contains alpha-gal, and that saliva is injected into the blood stream. The immune system then releases IgE antibodies to fight this foreign sugar. After this reaction, the future intake of mammal meat with the same alpha-gal causes an allergic reaction. Symptoms of the allergy reaction are caused by too many IgE antibodies attacking the allergen, in this case the alpha-gal

gladiator answered 1 year ago

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