Question

You just isolated a new strain of mutant mice, and preliminary mating suggest that the new mutant phenotype is not inherited in an autosomal fashion. Circumstantial evidence seems to indicate that the mutant phenotype may be following either an X-linked dominant or a mitochondrial-type inheritance pattern.

a.) What two informative crosses would you set up to distinguish between these two possibilities?

b.) How would the results distinguish between the two possibilities?

Answer 1

Answer:

• Not inherited autosomally: this means that the parents' sex plays a role in if the phenotype is inherited

X linked dominant: associated with X chromosome, inherited more by males

Mitochondrial inheritance: can only be inherited through the mother

• From the above information, we can figure that the phenotype comes from the mother since it is x-linked, mitochondrial inherited, and it is not inherited autosomally.
• To determine if this is true, it is best to cross the mother with many other male mice.
• If the offspring display the phenotype (specifically the male mice) we can conclude that the trait is most likely x-linked and comes from the mother mouse, which would mean that it has mitochondrial inheritance.
• Also, it would be a good idea to cross the father mouse with many other female mice.
• Determine if those offspring also have the phenotype.
• If they don't then the original mother is the only mouse with the distinct phenotype.
• If they do, that means that all of the female mice in the species carries this gene.

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