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6. If you created a mutant strain of mice that were not able to increase the...

6. If you created a mutant strain of mice that were not able to increase the concentration of CstF in B-lymphocytes following antigen activities of B-cell receptors (membrane bound antibodies), how would this impact antibody production and why?

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Expert Solution

According to the given question, class swithching is a necessary process by which IgM antibody produced during primary response get change in type and quality of antibody produced in the secondary response. This class swithching process is under genetic control by CstF. All B -lymphocyte start productive life as immature cells engaged in synthesis of mIgM. Mature B- cells express both mIgM and mIgD. Both are encoded on the same mRNA, and the decision to translate IgM and IgD heavy chains is made at the level of RNA splicing.During this switching process, their is only the Ch gene segment ; the same Vh gene segment continuous to be expressed. That's was why if their is mutation in CstF or decrease in concentration , it directly affects the antibody maturation and production.

gladiator answered 2 years ago
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