Question

1-Carbonic anhydrase inhibitors (check one or more)

None of the listed

Are used in the treatment of motion sickness

Inhibit carbonic anhydrase which is responsible for the interaction between carbon dioxide and water

Indapamide is the prototype

2-A woman with diabetes came to the hospital for a follow-up visit. She has tried to eat a healthier diet and work out over the past year months. She lost 8 kg with her new lifestyle. Nevertheless, her urine analysis displays some problems. The doctor decided to give the patient ramipril. What is a popular side effect of Ramipril ( choose one or more):

Gynecomastia

Ototoxicity

Acute renal failure

Hypokalemia

Nausea and vomiting

Hypertension

Answer 1

Qu1 . Correct option is 3.inhibit carbonic anhydrase enzymes which is responsible for interaction between Carbon dioxide and water.

Carbonic anhydrase inhibitors are class of pharmaceutical that suppress the activity of carbonic anhydrase enzyme. Carbonic anhydrase form a family of enzymes that catalyzes the interconversion between Carbon dioxide and water and dissociated ion of carbonic acid. ( Bicarbonate and hydrogen) .

Not others why

B) these drugs are used fluid from eyes Or glucoma

. These drugs do not act on antihistamins which are majorly responsible for Motion sickness.

D) indapamide is not prototype of carbonic anhydrase inhibitors, these are long acting diuretic. These drugs do not have thiazide like structure but are referred to thiazide like drugs.

Que2. Correct option is nausea and vomiting . And acute renal failure . As these drug are mostly recommended for, glomerular disease with proteinuria , as in diabetes , High blood sugar damaged the kidney so it not possible for maintaining the blood pressure thats why ramipril is given but there is Higher chances of renal failure . person may Have hyperkalemia Which cause electrolyte imbalance and Nausea and vomiting , along with acute renal failure because of hyperkalemia. Fluid imbalance may occur Because of vomiting anfdiarrhea .

Not others why

A) .Gynecomastia mostly occur growth hormone , psychetric drugs, anabolic steroids , estrogen but not by ramipril . As ramipril is drug for hypertension so it can impact kifney heart , bp but hormonal problems.

B) ototoxicity is not Side effect of the ramipril as ramipril reduce peripheral vascular resistance by inhibiting the formation of angiotensin 2, a potent vasoconstrictor. So there is very less chances of occuring ototoxicity.

D) as , Ramipril is ACE inhibitors , it Increases the potassium level to increase cardiac output to reduce hypertension. So no chance of hypokalemia.

E) as this drug is used for anti hypertensive action , so there is no chance of Hypertension, but there high risk of hypotension , If patient has taken overdose of drug.

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