Question

In: Chemistry

1) Succinyl-CoA inhibits both citrate synthase and α-ketoglutarate dehydrogenase. How is succinyl-CoA able to inhibit both...

1) Succinyl-CoA inhibits both citrate synthase and α-ketoglutarate dehydrogenase. How is succinyl-CoA able to inhibit both enzymes?

Solutions

Expert Solution

Thank You! Please rate my answer as "Thumbs Up" icon to support me if this answer finds helpful to you and is correct.


Related Solutions

Outline the mechanism of the conversion of α-ketoglutarate to succinyl-CoA catalyzed by α-ketoglutarate dehydrogenase complex. Put...
Outline the mechanism of the conversion of α-ketoglutarate to succinyl-CoA catalyzed by α-ketoglutarate dehydrogenase complex. Put these 5 steps in order: 1. decarboxylation 2. transacylation 3. dihydrolipoyl dehydrogenase activity 4. oxidation of 4-carbon group, reduction of lipoamide disulfide 5. enzymatical FADH2 reoxydation by NAD+
RELATED TO CELLULAR RESPIRATION 1. Drug A inhibits citrate synthase, an enzyme that catalyzes the synthesis...
RELATED TO CELLULAR RESPIRATION 1. Drug A inhibits citrate synthase, an enzyme that catalyzes the synthesis of citrate in the citrate acid cycle. In cells treated with Drug A, - Indicate whether the statements below are TRUE or FALSE. Acetyl-CoA levels will increase CO2 production will increase The rate of ATP production will decrease NADH will accumulate in the cell. 2. Drug B prevents NADH from donating electrons to Complex I in the ETC. Indicate whether the statements below are...
An antibiotic was discovered to inhibit citrate synthase. How many ATP would be produced per glucose...
An antibiotic was discovered to inhibit citrate synthase. How many ATP would be produced per glucose after the addition of the antibiotic Show all work.
Pyruvate dehydrogenase (PDH) kinase 1 (PDK1) phosphorylates and inhibits PDH and thusly increases citrate production for...
Pyruvate dehydrogenase (PDH) kinase 1 (PDK1) phosphorylates and inhibits PDH and thusly increases citrate production for lipid synthesis True/false?
a) Why is the formation of α-ketoglutarate strongly regulated? b) Isocitrate dehydrogenase is inhibited by ATP...
a) Why is the formation of α-ketoglutarate strongly regulated? b) Isocitrate dehydrogenase is inhibited by ATP and NADH and is activated by ADP. Assuming for a moment that not all of the allosteric effectors are known for this enzyme, propose one additional activator and one additional inhibitor. Justify the logic of your answer.
Which enzymatic action results in CO2 as a product? O Citrate Synthase O Succinyl-CoA Synthetase O...
Which enzymatic action results in CO2 as a product? O Citrate Synthase O Succinyl-CoA Synthetase O Isocitrate Dehydrogenase O Succinate Dehydrogenase O Malate Dehydrogenase
1. Acetyl CoA carboxylase . . . A. is activated by citrate B. is activated by...
1. Acetyl CoA carboxylase . . . A. is activated by citrate B. is activated by palmitate or palmitoyl SCoA C. is the rate-determining step of fatty acid breakdown D. B and C above E. A and B above 2. High density lipoproteins particles . . . A. transport endogenous lipids B. transport cholesterol from the liver to the tissues, predominantly C. A and B above D. None of the above above 3. Adipocytes . . . A. store large...
How much energy (in kJ/mol) is absorbed or released for the transfer of electrons from α-ketoglutarate...
How much energy (in kJ/mol) is absorbed or released for the transfer of electrons from α-ketoglutarate to NAD+?
Discuss the following enzymes: hexokinase, pyruvate dehydrogenase, ATP synthase and phosphofructokinase. -How do these enzymes interact...
Discuss the following enzymes: hexokinase, pyruvate dehydrogenase, ATP synthase and phosphofructokinase. -How do these enzymes interact with their substrates and catalyze reactions? -What is unique about each type of enzyme and why are each of the enzymes suited to the specific reactions which they catalyze including major points of regulation (enzyme catalysis, the mechanism of interaction of enzymes with their substrates and the effect of regulators/inhibitors on enzymes)? -What is the organization of the active site for each enzyme? Are...
Which pathway reduces the most NAD+? 1. Glycolysis 2. Pyruvate Dehydrogenase Complex 3. Both Pyruvate Dehydrogenase...
Which pathway reduces the most NAD+? 1. Glycolysis 2. Pyruvate Dehydrogenase Complex 3. Both Pyruvate Dehydrogenase Complex & Glycolysis are the same as each other but greater than fermentation 4. Fermentation
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT