Outline the mechanism of the conversion of α-ketoglutarate to succinyl-CoA catalyzed by α-ketoglutarate dehydrogenase complex. Put...

Outline the mechanism of the conversion of α-ketoglutarate to succinyl-CoA catalyzed by α-ketoglutarate dehydrogenase complex.

Put these 5 steps in order:

1. decarboxylation

2. transacylation

3. dihydrolipoyl dehydrogenase activity

4. oxidation of 4-carbon group, reduction of lipoamide disulfide

5. enzymatical FADH2 reoxydation by NAD+

Expert Solution

queen_honey_blossom answered 1 year ago

1) Succinyl-CoA inhibits both citrate synthase and α-ketoglutarate dehydrogenase. How is succinyl-CoA able to inhibit both...

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11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from...

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Briefly explain the steps by which the pyruvate dehydrogenase complex converts pyruvate to acetyl CoA and...

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The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle)....

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle). It is activated by AMP, CoA and NAD+, but it is inhibited by ATP, acetyl-CoA and NADH. What is the biochemical logic of this regulatory mechanism of the citric acid cycle? (In your response, be sure to address why specific molecules are activators and why specific molecules are inhibitors)

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase...

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