Question

In: Chemistry

Intercations between residues on seperate polypeptide chains would be best classified as: A) Primary B) Secondary...

Intercations between residues on seperate polypeptide chains would be best classified as:
A) Primary
B) Secondary
C) Quaternary
D) Global
E) Tertiary

Solutions

Expert Solution

The simplest level of protein structure, primary structure, is simply the sequence of amino acids in a polypeptide chain.

The next level of protein structure, secondary structure, refers to local folded structures that form within a polypeptide due to interactions between atoms of the backbone. (The backbone just refers to the polypeptide chain apart from the R groups – so all we mean here is that secondary structure does not involve R group atoms.) The most common types of secondary structures are the α helix and the β pleated sheet. Both structures are held in shape by hydrogen bonds, which form between the carbonyl O of one amino acid and the amino H of another.

The overall three-dimensional structure of a polypeptide is called its tertiary structure. The tertiary structure is primarily due to interactions between the R groups of the amino acids that make up the protein. R group interactions that contribute to tertiary structure include hydrogen bonding, ionic bonding, dipole-dipole interactions, and London dispersion forces – basically, the whole gamut of non-covalent bonds.

Tertiary structure is the next level of complexity in protein folding. Tertiary structure is the three-dimensional structure of a protein. While individual amino acids in the primary sequence can interact with one another to form secondary structures such as helices and sheets and individual amino acids from distant parts of the primary sequence can intermingle via charge-charge, hydrophobic, disulfide, or other interactions, the formation of these bonds and interactions will serve to change the shape of the overall protein. The folding that we end up with for a given polypeptide is the tertiary structure.

Answer is (C) Tertiary


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