Question

Name the drug and explain what effect it claims to have.

Garcinia Cambogia, a tropical fruit and a weight loss supplement

Based on your knowledge of biological theories, is there anything about how this drug is supposed to work that makes you suspicious? Explain.

Can you identify any credible science used in its claim? If so, in what way has the claim been exaggerated?

can you help me understand more about Garcinia Gambogia ? Specifically, can you provide a better answer to this question: Can you identify any credible science used in its claim? If so, in what way has the claim been exaggerated?

Answer 1

Garcinia cambogia is a plant of clusiaceae family . Its fruit exhibits pumpkin like longitudinal furrows and ridges over it but size is similar to guava .These are green or red colour in appearance.

Presence of useful chemicals like Hydroxy acetic acid ( glycolic acid) or 2-Hydroxy ethanoic acid ,cyanidin,isogarcinol ,garcinol etc. helps the fruit to exhibit medicinal use.Isogarcinol and garcinol bear the property to fight against parasites,bacteria , viral agents and inflammative substances .cyanidin acts as antioxidant in cells and keep cells young.Although cyanidin has radical scavenging capacity that destroy extra radicals which interrupt various metabolic reactions of cell,but cyanidin is unstable to behaviour of factors like pH,light,temperature etc.

• The active chemical contributing mòstly to this fruit's chemical composition is Hydroxyacetic acid.The activity of Hydroxyacetic acid of this fruit is truly very suspicious due to its fat metabolizing capacity. Reason:The fat or lipid metabolizing capacity Hydroxyacetic acid is due to
• it diminishes the conversion of carbohydrates into fat by preventing factors that convert citrate into lipids.
• By preventing conversion of glycogen into lipids in liver cells that help in loss of appetite and It burns the body fat naturally.
• It enhances fat burning by interfering with action of malonyl coenzyme A enzyme that helps in fatty acid  synthesis.
• It decreases the leptin level of serum .Leptin is a hormone that is encoded by obesity regulatory gene.

Different research regarding action of these chemicals of Garsinia cambogia has been continuing and contributing its advantages to pharmacology based on claim with scientific theories. But the claim has been exaggerating due to the problem with intake of the drugs having intake doses are not similar for absorption at buccal epithelium and intestinal epithelium.And this problem has solved by considering a proper dose healthy for both buccal and other gut tissues.