An antibody can bind to a coronavirus receptor with a koffand kon rate of 10-5s-1and 104M-1s-1,...

An antibody can bind to a coronavirus receptor with a k_offand k_on rate of 10^-5s^-1and 10⁴M^-1s^-1, respectively. If there are 10 µM total receptors and 50 µM free antibody, what concentration of coronavirus receptors are bound with antibody? What percent of receptors are bound?
The coronavirus mutated its receptor which changes the dissociation rate k_off to 1 s^-1for the antibody. How does this change the percent of receptors bounds?
How long does the antibody stay bound to the wildtype receptors vs. the mutated receptors?

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gladiator answered 1 year ago

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