Question

Question 36 (1 point)

Antibody-mediated destruction of the acetylcholine receptor at the postsynaptic membrane of the neuromuscular junction occurs in which of the following diseases?

Question 36 options:

	biliary cirrhosis
	Addison's
	multiple sclerosis
	myasthenia gravis

Question 37 (1 point)

IgA autoantibodies against gliadin, tissue transglutaminase, and endomysium are found in patients with the following disease.

Question 37 options:

	celiac
	Crohn's
	type 1 diabetes mellitus
	Addison's

Question 38 (1 point)

How should a patient with Hashimoto's disease be treated?

Question 38 options:

	placed on a gluten-free diet
	treat the symptoms, which sometimes resolves the situation
	given replacement therapy with glucocorticoids and mineralocorticoids
	given thyroid hormone replacement therapy

Question 39 (1 point)

How would you determine a diagnosis of celiac disease?

Question 39 options:

	triiodothyronine and thyroxine (T3 and T4) levels and antibodies to thyroglobulin and thyroperoxidase
	autoantibodies targeting the adrenal cortex
	IgA against tissue transglutaminase
	antibody to thyroid hormone-stimulating receptor, triiodothyronine and thyroxine (T3 and T4) levels

Question 40 (1 point)

Antibodies found in type 1 insulin-dependent diabetes include

Question 40 options:

	transglutaminase, insulin and insulin-associated antigen
	myelin basic protein, transglutaminase and insulin
	catecholamines, desmoglein, and insulin
	glutamic acid decarboxylase-65 (GAD-65), insulin associated antigen, and insulin

Answer 1

Question 36 : Myasthenia gravis

Myasthenia gravis is the autoimmune disease of the neuromuscular junction which is caused by the Antibody mediated destruction(alter,block or destroy) of the acetylcholine receptor at its postsynaptic membrane.This causes error in the neuromuscular transmission and prevent the muscle from contracting leading to the weakness of the skeletal muscle .

Question 37 : celiac

Celiac disease is a autoimmune disease and it is a immune reaction in response to gluten consumption.Gluten is a type of protein found in wheat and barley. Celiac disease can be identified by detecting tissue transglutaminase IgA antibodies (tTG), endomysial antibodies(EMA) and deamidated gliadin peptide (DGP)antibodies .

Question 38:given thyroid hormone replacement therapy.

Hashimoto's disease should be treated with thyroid hormone replacement therapy. Oral dose of levothyroxine sodium is the only drug of choice for lifelong .

Question 39: autoantibodies targeting the adrenal cortex IgA against tissue transglutaminase.

Tissue transglutaminase is an enzyme that fixes damages in the body . Individuals with celiac disease have antibodies produced by the body against this enzyme .The presence of this autoantibodies help in the diagnosis of celiac disease.

Question 40: glutamic acid decarboxylase-65 (GAD-65), insulin associated antigen, and insulin

Type I insulin dependent diabetes have islet cell autoantibodies(ICA) , antibodies to glutamic acid decarboxylase 65( GAD-65) , insulin autoantibodies(IAA) , islet tyrosine phosphatase 2 (IA-2A)

and these attack different parts of pancreas affecting it's normal function.