Question

what are the roles of insulin in the CNS paying particular attention to its role in energy homeostasis? (150 words)

(include references and images if you can)

thanks

Answer 1

Insulin is involved in multiple regulatory mechanisms including neuronal survival, learning, and memory, as well as in regulation of energy homeostasis.

Acute insulin action in the CNS helps to regulate whole-body metabolic function.

It also helps to the memory and cognitive function.

Insulin is a hormone produced by the pancreas that facilitates glucose transport into cells.

By facilitating glucose transport into cells from the blood stream, insulin lowers blood glucose levels.

Glucogon is a pancreatic hormone which increase the blood glucose levels. Glucogon and insulin has antagonistic effects. Insulin control the blood glucose levels. If glucose levels is increased CNS send message to pancreas and adjust the level of glucogon production.

Central nervous system (CNS) insulin signaling regulates energy and glucose homeostasis by acting on hypothalamic neurocircuits and higher brain circuits such as the dopaminergic system.

There are certain conditions such as type 2 DM , obestity etc which results in the insulin resistance in different areas of brain and there by altering the energy homeostasis and can result in diseases.