Classify each of the following situations as either "cooperativity" or "allostery": 1. An insulin binding to...

Classify each of the following situations as either "cooperativity" or "allostery":

1. An insulin binding to a GPCR triggers many conformational changes in the GPCR.

2. Annexins are remodeling proteins with membrane binding affinity that can be increased in the presence of calcium ions.

3. When valium (a narcotic) binds to a GABA receptor, the receptor's affinity for binding to GABA increases.

4. Once phosphorylated, phosphorylase kinase adopts a new structure that is functional.

Expert Solution

ANSWER:

Statement no 1- An insulin binding to a GPCR triggers many conformational changes in the GPCR. -- Allostery

Explanation : As insulin binding to the GPCR has triggered many conformational changes in the GPCR. Hence, the insulin ligand has changed the tertiary structure of the GPCR and its functionality. So it is an example of allostery binding.

Statement no 2 - Annexins are remodeling proteins with membrane binding affinity that can be increased in the presence of calcium ions. -- Cooperativity

Explanation : As the presence of Calcium ions has increased the affinity of the protein, So it is surely an example of positive cooperativity.

Statement no 3- When valium (a narcotic) binds to a GABA receptor, the receptor's affinity for binding to GABA increases.-- Cooperativity

Explanation : Upon binding of the Valium molecule to the receptor, the receptor's affinity for its ligand has increased. Therefore, it is an example of Positive Cooperativity.

Statement no 4- Once phosphorylated, phosphorylase kinase adopts a new structure that is functional.-- Allostery

Explanation : Phosphorylation of the enzyme phosphorylase kinase has induced structural change as well as functional change. So, this is clearly an example of allosteric interaction.

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Classify each of the following situations as either "cooperativity" or "allostery": 1. An insulin binding to...

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