Which of the following receptors are present on the heart? β1 (Beta 1) β2 (Beta 2)...

Which of the following receptors are present on the heart?

		β1 (Beta 1)
		β2 (Beta 2)
		α1 (Alpha 1)
		Both β-1 and α-1

Expert Solution

ANSWER

Beta 1 ( ß1)

Explanation:

Adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors .These are targets of many catecholamines like norepinephrine and epinephrine produced by the body.Five types of adrenergic receptors (receptors binding epinephrine): α1, α2, β1, β2, and β3.

Beta 1 - Also known as ADRB1 ,which is associated with Gs heterotrimeric G protein that are predominantly present in cardiac tissue.

Function : Activation of beta 1 receptor leads to increase in contractile force and heart rate.

Beta 2 - Also known as ADBR2 , they are expressed mainly in bronchioles of lungs and the arteries of the skeletal muscles.

Function : Cause dilation of bronchial passages, vasodilation in muscle and liver, relaxation of uterine muscle, and release of insulin.

Alpha 1 - Type of classic postsynaptic alpha receptors . Mainly found on vascular smooth tissue. Helps in determining arteriolar resistance, venous capacitance and thus regulating BP.

Function: As alpha receptor is stimulated by epinephrine or norepinephrine, the arteries constrict. This increases the blood pressure and the blood flow returning to the heart.

Sydney Mullin answered 2 years ago

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