Question

What would happen to the development of the drosophila if the activator inhibitor present in the metathorax region was non-functional?

Answer 1

Drosophila melanogaster is a model organism essentially applied in genetic research that brings promising advantages into studying preclinical nutrigenomics.   Drosophila somatic muscle, cardiac muscle, and the visceral muscle all develop from the mesoderm, which is the layer of cells between the endoderm and ectoderm in the gastrula. It is specified in the ventral region of the syncytial blastula embryo. At gastrulation the mid-ventral cells invaginate and spread in a layer under the ectoderm to form the mesoderm proper. At this stage they are not committed to a specific cell fate. Then, during the next few hours, the embryo becomes segmented and each mesodermal segment becomes subdivided along the anterior-posterior (A/P) and dorsal-ventral (D/V) axes . The cells proliferate, diversify, and commit to different cell fates that include the three major muscle types together with other mesodermal derivatives (e.g., the fat body, which is equivalent to vertebrate liver). Concurrently, the mesoderm begins to separate into two cell layers, classically known as the somatic and splanchnic mesoderm. The somatic muscles derive from the external, somatic mesoderm and the visceral muscles derive from the internal, splanchnic mesoderm.3 The cardiac muscle derives from the most dorsal, external mesodermal cells. Progenitor populations of each of these derivatives develop at specific positions along the A/P and D/V axes in each segment. How the heart and visceral muscle subsequently develop from these cells is described later.