The first level of the motor system hierarchy is the spinal
cord, the location of the alpha motor neurons that constitute the
“final common pathway” of all motor commands. Alpha motor neurons
directly innervate skeletal muscle, causing the contractions that
produce all movements. Reflex circuits and other circuitry within
the spinal cord underlie the automatic processing of many of the
direct commands to the muscles (the “nuts and bolts” processing),
thereby freeing higher-order areas to concentrate on more global,
task-related processing.
Motor system dysfunction can result from damage or disease at
any level of the motor system hierarchy and side-loops. Differences
in the symptoms that result from damage at different levels allow
the clinician to localize where in the hierarchy the damage is
likely to be. Damage to alpha motor neurons
results in a characteristic set of symptoms called the lower motor
neuron syndrome (lower motor neurons refer to alpha motor neurons
in the spinal cord and brain stem; all motor system neurons higher
in the hierarchy are referred to as upper motor neurons). This
damage usually arises from certain diseases that selectively affect
alpha motor neurons (such as polio) or from localized lesions near
the spinal cord. Lower motor neuron syndrome is characterized by
the following symptoms:
- The effects can be limited to small groups of muscles. Recall
that a motor neuron pool is a nucleus of alpha
motor neurons that innervate a single muscle (link to Motor Unit
Figure 2). Furthermore, nearby motor neuron pools control nearby
muscles. Thus, restricted damage to lower motor neurons, either
within the spinal cord or at the ventral roots, will affect only a
restricted group of muscles.
- Muscle atrophy. When alpha motor neurons die, the muscle fibers
that they innervate become deprived of necessary trophic factors
and eventually the muscle itself atrophies.
- Weakness. Because of the damage to alpha motor neurons and the
atrophy of muscles, weakness is profound in lower motor neuron
disorders.
- Fasciculation. Damaged alpha motor neurons can produce
spontaneous action potentials. These spikes cause the muscle fibers
that are part of that neuron’s motor unit to fire, resulting in a
visible twitch (called a fasciculation) of the affected muscle
- Fibrillation. With further degeneration of the alpha motor
neuron, only remnants of the axons near the muscle fibers remain.
These individual axon fibers can also generate spontaneous action
potentials; however, these action potentials will only cause
individual muscle fibers to contract. This spontaneous twitching of
individual muscle fibers is called a fibrillation (Fig. 1).
Fibrillations are too small to be seen as a visible muscle
contraction. They can only be detected with electrophysiological
recordings of the muscle activity (an electromyogram).
- Hypotonia. Because alpha motor neurons are the only way to
stimulate extrafusal muscle fibers, the loss of these neurons
causes a decrease in muscle tone.
- Hyporeflexia. The myotatic (stretch) reflex is
weak or absent with lower motor neuron disorders, because the alpha
motor neurons that cause muscle contraction are damaged.