What evidence supports/refutes the neurodevelopmental theory of Schizophrenia?

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Schizophrenia is a neurodevelopmental disorder that affects youth in puberty and is manifested by a disruption in cognition and emotion along with negative (ie, avolition, alogia, apathy, poor or nonexistent social functioning) and positive (presence of hallucinations, delusions) symptoms.
Cerebral ventricular enlargement is the best-replicated finding, and this tends to be associated with impairment of neuropsychological performance. The idea that these abnormalities have a neurodevelopmental origin gains indirect support from the, admittedly less consistent, evidence of abnormalities of cerebral asymmetry and of neuronal migration in adult schizophrenics, as well as from the better established behavioral, psychomotor, and cognitive impairments reported in pre-schizophrenic children. However, the relationship between childhood and adult neuropsychological and brain structural findings has not been proven, and we do not know whether only some schizophrenia has a developmental origin, or whether patients differ only in the degree of developmental impairment that they show.

Hayet Jeridi answered 9 months ago

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