Question

6. How does the mechanism by which diuresis occurs with diabetes insipidus differ from that which
occurs in diabetes mellitus?

8. What other conditions result in polyuria and polydipsia (pu/pd)?

9. What is ddavp and how is it administered?

Answer 1

6.

Mechanism of diuresis in diabetes insipidus:-

ADH is the antidiuretic hormone responsible for water reabsorption and controls the diuresis.

Diuresis in diabetes insipidus is resulted from lack of antidiuretic hormone.

Mechanism of diuresis in diabetes mellitus:-

In diabetes mellitus diuresis is due to the high concentration of blood sugar will be eliminated in the urine, taking along any excess water.

8.

Other conditions results in polyuria and polydipsia:-

Other than diabetes mellitus and insipidus number of other conditions results in polyuria and polydipsia. They are as below:-

• Urinary infection
• If consumed alcohol or coffee
• Kidney diseases like acute renal failure
• Thyroid disease
• Adrenal gland disease
• Taking certain medications like steroids

9.

DDAVP is 1-deamino-8-D-arginine vasopressin. It is the man made hormone similar to the ADH. It is used to contrast the polyuria.

It can be administered as Spray through nasal route or through Intravenously or by oral as tablet.