How is carbonic anhydrase important in gas transport?

Expert Solution

- Carbonic anhydrase is a metalloenzyme containing zinc ion. It catalyses the following reaction :-

CO2 + H20 --> H2CO3 --> H+ + HCO3- . This is a reversible reaction catalysed by the enzyme carbonic anhydrase.

- The role of carbonic anhydrase in gas transport is in the transportation of carbon dioxide in the blood in the form of bicarbonate ions.

- About 70% of carbon dioxide is transported as bicarbonates in plasma and red blood cells (RBCs). RBCs contain very high level of carbonic anhydrase that helps in the conversion of carbon dioxide to carbonic acid and bicarbonates and thus helping in transportation of carbon dioxide.

- Carbon dioxide released from the tissues enter the plasma and immediately diffuses into the RBCs where carbon dioxide is converted into carbonic acid which dissociates into bicarbonates and hydrogen ions. This is a reversible reaction.

- Thus, the function of carbonic anhydrase in gas transport is to transport carbon dioxide in the blood as bicarbonates.

Sydney Mullin answered 1 year ago

Carbonic anhydrase is an enzyme that catalyzes the interconversion of carbon dioxide and water to bicarbonate...

Carbonic anhydrase is an enzyme that catalyzes the interconversion of carbon dioxide and water to bicarbonate and a proton: CO2 + H2O ? HCO3- + H+ This enzyme is necessary for the reaction shown above to occur rapidly enough for normal kidney function. Which of the following might you expect to occur if we inhibited the carbonic anhydrase present in renal tubular cells? increased excretion of protons into the lumen of the renal tubule respiratory alkalosis metabolic acidosis

1. Carbonic anhydrase catalyzes the reverse reaction (of course!): HCO3 - + H+  CO2 +...

1. Carbonic anhydrase catalyzes the reverse reaction (of course!): HCO3 - + H+  CO2 + H2O Initial velocities were measured at the following concentrations of HCO3 - (The enzyme concentration was 0.0025 mg/ml; the enzyme Mr = 29,100 Da.): [HCO3 -] mM 1.3 2.6 6.5 13.0 26.0 vo (µM/sec) 2.5 4.00 6.30 7.60 9.00 vo (µM/sec) with acetazolamide 1.17 2.10 4.00 5.70 7.20 a. Do the required calculations and graph the results as a Lineweaver-Burk plot. Use the X-...

The data to the below were collected for the bovine carbonic anhydrase-catalyzed reaction described by CO2...

The data to the below were collected for the bovine carbonic anhydrase-catalyzed reaction described by CO2 (aq) + H2O (l) -->H+ (aq) + HCO3- (aq) [CO2] (mmol * L^-1) R (Ýµmol * L^-1 * s^-1) 1.25 28.74 2.50 48.61 5.00 80.28 20.00 155.59 Use these values to determine the value of KM, the Michaelis-Menten constant. Answer the four parts below. a) If you were to plot this data to graphically determine Rmax and KM using a Lineweaver-Burk plot, what would...

1-Carbonic anhydrase inhibitors (check one or more) None of the listed Are used in the treatment...

1-Carbonic anhydrase inhibitors (check one or more) None of the listed Are used in the treatment of motion sickness Inhibit carbonic anhydrase which is responsible for the interaction between carbon dioxide and water Indapamide is the prototype 2-A woman with diabetes came to the hospital for a follow-up visit. She has tried to eat a healthier diet and work out over the past year months. She lost 8 kg with her new lifestyle. Nevertheless, her urine analysis displays some problems....

A human carbonic anhydrase mutant H64A binds well to Zn, which binds well to the substrate...

A human carbonic anhydrase mutant H64A binds well to Zn, which binds well to the substrate water. However, the kcat is much lower than that of the wildtype, particularly at low pH. What might explain this?

pharmacology question Briefly explain why a Carbonic Anhydrase Inhibitor would cause more pronounced hypokalemia than a...

pharmacology question Briefly explain why a Carbonic Anhydrase Inhibitor would cause more pronounced hypokalemia than a typical thiazide diuretic.

Carbonic anhydrase (CA) has a 25,000-fold higher activity (kcat = 106 s-1) than orotidine monophosphate decarboxylase...

Carbonic anhydrase (CA) has a 25,000-fold higher activity (kcat = 106 s-1) than orotidine monophosphate decarboxylase (OMPD) (kcat = 40 s-1). However, OMPD provides more than a 1010 higher “rate acceleration” than CA. Explain how this is possible.

One of the many remarkable enzymes in the human body is carbonic anhydrase, which catalyzes the interconversion of carbon dioxide and water with bicarbonate ion and protons.

One of the many remarkable enzymes in the human body is carbonic anhydrase, which catalyzes the interconversion of carbon dioxide and water with bicarbonate ion and protons. If it were not for this enzyme, the body could not rid itself rapidly enough of the CO2 accumulated by cell metabolism. The enzyme catalyzes the dehydration (release to air) of up to 107 CO2 molecules per second. Which components of this description correspond to the terms enzyme, substrate, and turnover number?

Gas Transport in the Blood. Describe in detail how carbon dioxide is transported in the blood....

Gas Transport in the Blood. Describe in detail how carbon dioxide is transported in the blood. Be sure to include all the ways the blood transports carbon dioxide and a detailed explanation/description of how carbon dioxide is “loaded” and “unloaded” from the blood both in the tissues and the alveoli.

1. Gas Exchange and Transport (1C) Discuss the effect of bicarbonate on oxygen transport. With more...

1. Gas Exchange and Transport (1C) Discuss the effect of bicarbonate on oxygen transport. With more explanation

Question