Question

Carbonic anhydrase is an enzyme that catalyzes the interconversion of carbon dioxide and water to bicarbonate and a proton:

CO2 + H2O ? HCO3- + H+

This enzyme is necessary for the reaction shown above to occur rapidly enough for normal kidney function. Which of the following might you expect to occur if we inhibited the carbonic anhydrase present in renal tubular cells?

increased excretion of protons into the lumen of the renal tubule

respiratory alkalosis

metabolic acidosis

Answer 1

Answer

if we inhibited the carbonic anhydrase present in renal tubular cells-

carbonic anhydrases  catalyze the production of HCO₃⁻ and H⁺ from H₂O and CO_2.

if we inhibited the carbonic anhydrase in renal tubular cells then carbonic anhydrase in the luminal membrane also inhibited, that decrease the normal speed of bicarbonate formation from carbonic acid as well as decreases the diffusion of CO₂ into the tubular cells.

• In respiratory acidosis, more proton pumps are inserted into the lumen of the renal tubule. it also Increase in the negative potential inside the tubule because concentration of  PO₄^-, SO₄^- or HCO₃^- increase inside due to the slow absorption.
• Respiratory alkalosis - Increase in  respiration leads to increase the level of blood pH beyond the normal range (7.35–7.45) with a subsequent decrease in the  carbon dioxide levels in the arteries. It causes Hyperventilation, and Pulmonary disorder. so when we inhibited the carbonic anhydrase the concentration of carbon dioxide increases inside the cells leads to increase in the pH in the blood stream.
• Metabolic acidosis - when the kidneys was unable to remove the excess acids from the body. it causes gastrointestinal bicarbonate loss, renal tubular acidosis, hyperkalemia, and renal failure.