Question

Describe nicotinic receptors, adrenergic receptors, muscarinic receptors in detail.

Answer 1

• Nicotinic receptors are polypeptides which respond to acetylcholine. They are the cholinergic receptors which are found in central and peripheral nervous system , muscles and other tissues. They are also called as nAChRs ( Nicotinic acetylcholine receptor). Its function is to trigger neuromuscular transmission.
  
• Adrenergic receptors targets catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline). They belong to class of G protein coupled receptor. These receptors are of different types alpha, beta 1 and beta 2. Adrenergic receptors increases cardiomyocyte contractility to maintain the ventricular function.
  
• Muscarinic receptors helps in the transduction of cholinergic signals in central nervous system, autonomic ganglia, smooth muscles and other parasympathetic ends of organs. They are also known as mAChRs (Muscarinic acetylcholine receptors). They form G protein coupled receptor complex in the cell membrane.