Describe nicotinic receptors, adrenergic receptors, muscarinic
receptors in detail.
Describe nicotinic receptors, adrenergic receptors, muscarinic
receptors in detail.
Solutions
Expert Solution
Nicotinic receptors are polypeptides which respond to
acetylcholine. They are the cholinergic receptors which are found
in central and peripheral nervous system , muscles and other
tissues. They are also called as nAChRs ( Nicotinic acetylcholine
receptor). Its function is to trigger neuromuscular
transmission.
Adrenergic receptors targets catecholamines like norepinephrine
(noradrenaline) and epinephrine (adrenaline). They belong to class
of G protein coupled receptor. These receptors are of different
types alpha, beta 1 and beta 2. Adrenergic receptors increases
cardiomyocyte contractility to maintain the ventricular
function.
Muscarinic receptors helps in the transduction of cholinergic
signals in central nervous system, autonomic ganglia, smooth
muscles and other parasympathetic ends of organs. They are also
known as mAChRs (Muscarinic acetylcholine
receptors). They form G protein coupled receptor complex in the
cell membrane.
Describe the two broad classes of cholinergic receptors:
nicotinic and muscarinic, provide details relating to the
termination of ACh action (150-word limit).
2 ) Explain why the M2 subtype of muscarinic ACh receptors is
found on the autorhythmic cells of the sinoatrial node and the M3
subtype is found on smooth muscle fibers of the bronchioles. (6
pts)
If a cell has muscarinic cholinergic receptors, you know it is
NOT
a. smooth muscle.
b. skeletal muscle.
c. an endocrine gland.
d. cardiac muscle.
e. an adipose cell
Explain why the M2 subtype of muscarinic ACh receptors is found
on the autorhythmic cells of the sinoatrial node and the M3 subtype
is found on smooth muscle fibers of the bronchioles.