Question

Complete the following paragraph to explain the relationship between nicotinic and muscarinic cholinergic receptors

Answer 1

the two cholineric receptors are based on the agonists muscarine and nicotine, respectively

Nicotinic : Nicotinic receptors are characterised through their interaction with nicotine in tobacco.  These are ligand-gated ion channels that form pores in cells’ plasma membranes, mediating fast signal transmission at synapses. these receptors are physiological processes, and can be either neuronal or muscle-type. they are involved in cognitive function, learning and memory, arousal, reward, motor control and analgesia.

Muscarinic: these are characterised by their interaction with muscarine, a water-soluble toxin derived from the mushroom. The interaction cause activation of the peripheral sympathetic nervous system which may cause death. The muscarinic receptors occur primarily in the Central Nervous System. They are part of a large family of G-protein-coupled receptors (‘G proteins’). They inhibit the cardiac muscle , exiting the smooth muscle and gland