Question

In: Biology

GENETICS 1) What are all the types of mutations/Errors found in each of the following: Eukaryotic...

GENETICS

1) What are all the types of mutations/Errors found in each of the following: Eukaryotic transcriptional regulation, DNA repair, and inherited mutation in the gene coding region? Be sure to DETAILED everything and provide multiple examples for each of the types of mutations/ errors that goes in each of the mechanisms. Explain specifically how each process could cause illness, for example in humans and other eukaryotic organisms.

It will be awesome if you can provide all the mutations in each mechanisms. Thank you in advance.

Solutions

Expert Solution

Mutation in Eukaryotic Transcription Regulators:

            Transcription factors are proteins that regulate the transcription of genes—that is, their copying into RNA, on the way to making a protein. In humans and other eukaryotes, RNA polymerase can attach to the promoter only with the help of proteins called basal (general) transcription factors. They are part of the cell's core transcription toolkit, needed for the transcription of any gene. There is a large class of transcription factors that control the expression of specific, individual genes. For instance, a transcription factor might activate only a set of genes needed in certain neurons.

Mutation in transcription factor: One or more transcriptional factors are required for a gene express. Some function as gene activators, some others act as inhibitors. They play a great role in feedback mechanism also. Mutation in transcription factor either results in permanent loss of function or permanent gain of function. A loss-of-function mutation results in a gene product (transcription factor) that either does not work or works too little; thus, it can reveal the normal function of the gene. A gain-of-function mutation results in a gene product that works too much, works at the wrong time or place, or works in a new way. Gain of function mutation in transcription promoters and loss of function in transcription inhibitors hugely affects cell cycle machinery, hormone secretion, enzyme actions and can cause dreaded disease like cancer.

Example:

Gene

Function

Cancer Type

GFl 1

Transcriptional Repressor

Medulloblastoma

MYB

Transcriptional factor

Adenoid cystic Carcinoma

Mutation in DNA repair:

            DNA damage is a change in the basic structure of DNA that is not itself replicated when the DNA is replicated. A DNA damage can be a chemical addition or disruption to a base of DNA (creating an abnormal nucleotide or nucleotide fragment) or a break in one or both chains of the DNA strands. When DNA carrying a damaged base is replicated, an incorrect base can often be inserted opposite the site of the damaged base in the complementary strand, and this can become a mutation in the next round of replication. Also DNA double-strand breaks may be repaired by an inaccurate repair process leading to mutations. In addition, a double strand break can cause rearrangements of the chromosome structure (possibly disrupting a gene, or causing a gene to come under abnormal regulatory control), and, if such a change can be passed to successive cell generations, it is also a form of mutation.

            Mutations, however, can be avoided if accurate DNA repair systems recognize DNA damages as abnormal structures, and repair the damages prior to replication.

            If DNA damages in proliferating cells are not repaired due to inadequate expression of a DNA repair gene, this increases the risk of cancer. In contrast, when DNA damages occur in non-proliferating cells and are not repaired due to inadequate expression of a DNA repair gene, the damages can accumulate and cause premature aging.

Example:

BRACA1 and BRACA2 genes normally play a big role in preventing breast cancer. They help repair DNA breaks that can lead to cancer and the uncontrolled growth of tumors. Because of this, the BRCA genes are known as tumor suppressor genes. However, in some people these tumor suppression genes do not work properly. When these genes become altered or broken as a result of mutation, it doesn’t function correctly and causes breast cancer.

Inherited mutation:

The mutations inherited from your parents, are called germ-line mutations. Some well-known inherited genetic disorders include cystic fibrosis, sickle cell anemia, Tay-Sachs disease, phenylketonuria and color-blindness, among many others. All of these disorders are caused by the mutation of a single gene.

            Most inherited genetic diseases are recessive, which means that a person must inherit two copies of the mutated gene to inherit a disorder. This is one reason that marriage between close relatives is discouraged; two genetically similar adults are more likely to give child two copies of a defective gene.

            Diseases caused by just one copy of a defective gene, such as Huntington's disease, are rare. Thanks to natural selection, these dominant genetic diseases tend to get weeded out of populations over time, because afflicted carriers are more likely to die before reproducing.

            Scientists estimate that every one of us has between 5 and 10 potentially deadly mutations in our genes-the good news is that because there's usually only one copy of the bad gene, these diseases don't manifest.


Related Solutions

1. What are the functions of the following elements found in eukaryotic cells? a) lysosome b)...
1. What are the functions of the following elements found in eukaryotic cells? a) lysosome b) Golgi apparatus c) mitochondria d) endoplasmic reticulum
Ribosomes can normally be found in all of the following eukaryotic cell locations except: A. the...
Ribosomes can normally be found in all of the following eukaryotic cell locations except: A. the outer nuclear membrane B. the rough endoplasmic reticulum C. the mitochondrion D. the inner nuclear membrane E. the chloroplast
What effect on phenotype will occur on the following types of mutations: 1. Base Substitution 2....
What effect on phenotype will occur on the following types of mutations: 1. Base Substitution 2. Thymine Dimers 3. Indels 4. Nucleotide Expansion 5. Larger lesions (duplication, deletions, inversion, translocation)
1. How are Sampling Errors and Nonsampling Errors different? 2. What types of errors do you...
1. How are Sampling Errors and Nonsampling Errors different? 2. What types of errors do you feel are most critical? (It needs to be about 2 paragraphs)
Match the following errors to the types of errors that are not revealed by the trial...
Match the following errors to the types of errors that are not revealed by the trial balance.                                                                                                Error Types of errors a. Goods bought on credit were credited in the Purchases account. Commission b. Sold goods to B Brown and debited F Brown’s account. Original entry C Paid rent for P6, 500 but recorded P5, 600 in the books of accounts. Principle a. A cash sale of P600 was incorrectly entered as P500 in the books of accounts. Transposition b....
Which of the following types of mutations can affect the length of the mRNA molecule?Check all...
Which of the following types of mutations can affect the length of the mRNA molecule?Check all that apply. Check All That Apply Substitution mutation in an intron.Substitution mutation in an intron. Deletion of 1 nt in an exon.Deletion of 1 nt in an exon. Deletion of 2 nt within an intron that does not affect splicing.Deletion of 2 nt within an intron that does not affect splicing. Addition of 3 nt within an exon.Addition of 3 nt within an exon....
What are the differences between synonymous and nonsynonymous mutations? What types of point mutations (frameshift, missense,...
What are the differences between synonymous and nonsynonymous mutations? What types of point mutations (frameshift, missense, nonsense, and silent) fall under synonymous and nonsynonymous? Are synonymous and nonsynonymous mutations cis or trans?
What is the likely effect of each of the following mutations of the trpL region on...
What is the likely effect of each of the following mutations of the trpL region on attenuation control of trp operon gene transcription? Explain your reasoning. a. Region 3 is deleted. b. Region 4 is deleted. c. The entire trpL region is deleted. d. The start (AUG) codon of the trpL polypeptide is deleted. e. Two nucleotides are inserted into the trpL region immediately after the polypeptide stop codon. f. Twenty nucleotides are inserted into the trpL region immediately after...
What types of bond would be found within each water molecules and what types of bonds...
What types of bond would be found within each water molecules and what types of bonds would connect the two water molecules together? Furthermore, when relevant, where would the electrons be positioned in these bonds (ie. in the middle of the bond, or closer to one of the elements)? Be sure to be specific as to what bonds you are referring to when answering this question (it might not apply for all bond types). Finally, would any full or partial...
1.) Which of the following are elements involved in eukaryotic transcriptional regulation? a.) All of the...
1.) Which of the following are elements involved in eukaryotic transcriptional regulation? a.) All of the choices are correct b.) promoters c.)enhancers d.)silencers e.)transcriptional elements 2.) The tryptophan operon is repressible opeon that is a.) turned off whenever tryptophan is added to the growth medium. b.)turned on only when tryptophan is present in the growth medium. c.) permanently turned on. d.) turned on only when glucose is present in the growth medium
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT