Question

a) Does the composition of ECM has any active role to play in modulating the dynamic biomolecule organization(s) of cells during mechanotransduction?

b) Any possible role(s) played by plasma membrane in the structural transformation upon mechanotransduction?

Answer 1

a) mechanotransduction is a process by which mechanical properties of the extracellular environment induce intracellular response Within the cytoplasm and nucleus leading to changes in cell behaviour, or cell fate specification.Within microenvironment, the extracellular matrix (ECM)is an important supports structure that provides dynamic signaling cues in part through its physical, chemical and mechanical properties. in response to ECM factors, cell activate biochemical and mechanotransduction that modulate their survival, growth, migration, differntiation and function. This is describe the role of chemical composition, spatial patterning and mechanical stimulation in the specification of cardiovascular images with focus on the stem differentiation, direct transdifferentiation and endothelial to mesenchymal transition.

b) Plasma membrane is a key interface mediating both cellular response to mechanical stimuli and subsequent biochemical response.The molecular involved in PM mechanochemical transduction include sensor of unfolding, membrane tension etc. So these are the role played by plasma membrane.