what is the physiological importance and functions of the cellular
phospholipid bilayer?
what is the physiological importance and functions of the cellular
phospholipid bilayer?
Solutions
Expert Solution
Ans:
The phospholipid bilayer is a
universal component of all cell membranes. Its role is very
important because its structural components provide the barrier
that marks the boundaries of a cell. The structure is called a
"lipid bilayer" because it is composed of two layers of lipids
organized in two sheets.
The structure of the phospholipid
bilayer explains its function as a barrier. There are two important
regions of a lipid that provide the structure of the phospholipid
bilayer. Each lipid molecule contains a hydrophilic region, also
called a polar head region, and a hydrophobic, or nonpolar tail
region.
The most abundant class of lipid
molecule found in cell membranes is the phospholipid. A
phospholipid is a lipid that contains a phosphate group and is a
major component of cell membranes. A phospholipid consists of a
hydrophilic (water-loving) head and hydrophobic (water-fearing)
tail.
The phospholipids organize
themselves in a bilayer to hide their hydrophobic tail regions and
expose the hydrophilic regions to water. This organization is
spontaneous, meaning it is a natural process and does not require
energy. This structure forms the layer that is the wall between the
inside and outside of the cell.
The cell membranes of almost all
organisms and many viruses are made of a lipid bilayer, as are the
nuclear membrane surrounding the cell nucleus, and other membranes
surrounding sub-cellular structures. The lipid bilayer is the
barrier that keeps ions, proteins and other molecules where they
are needed and prevents them from diffusing into areas where they
should not be.
Phospholipid bilayers are critical
components of cell membranes. The lipid bilayer acts as a barrier
to the passage of molecules and ions into and out of the cell.
However, an important function of the cell membrane is to allow
selective passage of certain substances into and out of cells. This
is accomplished by the embedding of various protein molecules in
and through the lipid bilayer . These proteins form channels
through which certain specific ions and molecules are able to move.
Many membrane proteins also contain attached carbohydrates on the
outside of the lipid bilayer, allowing it to form hydrogen bonds
with water.
Answer in 2 sentences. Describe the structure of a phospholipid and
phospholipid bilayer.
Answer in 2 sentences. How does the organization of membranes
provide for transport and recognition.
The membrane of a cell is made mostly of a phospholipid bilayer
(with proteins and other molecules embedded in it). Explain how the
chemical properties of phospholipids make the cell membrane an
effective barrier against ions while at the same time allowing
non-polar molecules like oxygen to cross freely.
Explain step by step how a triglyceride would become a
phospholipid bilayer. Describe what bonds must be broken or formed
(such as ester bonds) and what molecules are consumed or created
(such as H2O) and what types of reactions these occur under (such
as concentration reactions).Hint: Remember that a phospholipid bilayer must contain
both phosphate and a polar head! Dont forget to mention what type
of bond connects your phosphate to the glycerol, etc,
etc!)
Which of the following would be expected to lower the Tm for a
phospholipid bilayer?
replacing a lipid containing unsaturated fatty acids with one
containing saturated fatty acids.
replacing a lipid containing 18-C fatty acids with one
containing 16-C fatty acids.
adding ions to bind to charged groups in the polar head
groups.
decreasing the concentration of phospholipids.
What would happen to a lipid bilayer if:
•Hydrocarbon chain length was reduced
•Each phospholipid molecule were covalently linked to a
hydrocarbon tail from the other side of the bilayer
•The layer contained a mix of phospholipids—one with two
unsaturated tails, one with two saturatedtails (would they interact
with each other equally, or would you see some organizaion?)
1) How would you differentiate hydrophobic and hydrophilic portions of a phospholipid bilayer?
Explain the importance of hydrophobic and hydrophilic regions of a phospholipid bilayer.
2) What are some differences between the production of glucoses and gluconeogenesis, and why does gluconeogenesis require a higher amount of ATP?
Utilize examples and thoroughly explain the differences.
If we added a high concentration (which will permeabilize the
phospholipid bilayer) of strong detergents to beet samples, would
this result in high or low absorbance value at 460 nm? Explain.
What are the physiological effects of Congestive Heart
Failure at the cellular, tissue and organ system levels as
relevant. What mechanisms fail at the cellular level that disrupts
homeostasis? What are the effects on the body as a result of CHF
disease?