Question

Outline the effects and possible causes and treatments for hypercortisolism and hypocortisolism.

Outline the complete pathway of Cortisol secretion and control.

Answer 1

ANS)

Effects of Hypercortisolism

High cortisol level can make some of hallmark indications of the Cushing syndrome.Cushing syndrome can make a fatty protuberance between the shoulders, rounded face,pink coloured stretch spots in the dermis.This Cushing Syndrome can also leads to enhanced BP and type 2 diabetes.

Causes of Hypercortisolism

Cushing syndrome takes place when the human body is subjected to enhanced ranges of the cortisol hormone for extended period of time.The Cushing syndrome can also called as the hypercortisolism and it can be resulted by the utilization of oral corticosteroid drugs.This may also happens when the human body produce lots of cortisol by its own.

Treatment of Hypercortisolism

The drug to reduce the increased formation of cortisol at adrenal gland involve mitotane ,metyrapone and also the Ketoconazole.The medicines like Mifepristone is accepted for the individuals with cushing syndrome who is suffering from the type 2 diabetes .

Effects of Hypocortisolism

Drastic fatigue,decreased blood sugar,Vomitting,diarrhea,stomach ache,hyperpigmentation,loss of appetite.

Causes of Hypocortisolism

Usual reason of Hypocortisolism or Addison's disorder is a autoimmune complication.At the time when the immune system become defective and affects and harms their own body,in this case mainly the adrenal gland and some of the other common reason or cause involve the Tuberculosis and fungal infections.

Treatment of Hypocortisolism

The normal tratment include the medications.The hormone replacement therapy will be done to correct the ranges of the steroid hormones the body isn't making.Some of the alternatives for hypocortisolism involve the oral corticosteroids like the Hydrocortisone and methylprednisolone to exchange the cortisol.

PATHWAY OF CORTISOL SECRETION AND CONTROL

The initial regulation of cortisol is pituitary gland peptide,Adreno cortico tropic hormone,which very likely regulate the cortisol by controlling the motion of calcium into the cortisol-releasing target cells.The Adreno cortico tropic hormone is successively regulated by the hypothalamic peptide corticotropin-releasing hormone,that is in the nervous regulation.

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