Question

Outline the effects and possible causes and treatments for hypercortisolism and hypocortisolism. Outline the complete pathway of Cortisol secretion and control.

Answer 1

Effects of hypercortisolism

High cortisol level can make some of hallmark indications of the Cushing syndrome. Cushing syndrome can make a fatty protuberance between the shoulders, rounded face, pink coloured stretch spots in the dermis. This Cushing syndrome can also leads to enhanced BP and type 2 diabetes

Causes of Hypercortisolism

Cushing syndrome takes place when the human body subjected to enhanced ranges of the cortisol hormone for extended periods of time. The Cushing syndrome can also called as the hyercortisolism and it can be resulted by the utilization of oral corticosteroid drugs. This may also happen when human body produce lots of cortisol by its own

Treatment for Hypercortisolism

The drug to reduce the increased formation of cortisol at adrenal gland involve mitotane, metyrapone, and also the Ketoconazole. The medicines like mefiprestone is accepted for the individuals with Cushing syndrome who is suffering from the type 2 diabetes

Effects of Hypocortisolism

Drastic fatigue, decreased blood sugar, vomiting, diarrhea, stomach ache, hyperpigmentation, loss of appetite

Causes of Hypocortisolism

Usual reason of Hypocortisolism or addisoms disorder is a autoimmune complication. At the time when immune system became defective, affects and jarms their own body. In this case mainly the adrenal gland and some of the other common reason or cause involves the Tuberculosis and fungal infections

Treatment of Hypocortisolism

The normal treatment includes the medications. Hormone replacement therapy will be done to correct the ranges of steroid hormones the body isn't making some of the alternatives for Hypocortisolism involves the oral corticosteroids like hydrocortisone and Methylprednisolone to exchange the cortisol.

Pathway of cortisol secretion and control

The initial regulation of cortisol is pituitary gland peptide, adreno cortico tropic hormone. Which very likely regulate the cortisol by controlling the motion of calcium into the cortisol releasing target cells. The adreno cortico tropic hormone successively regulated by the hypothalamic peptide cortico tropine releasing hormone. That is in the nervous regulation