In: Anatomy and Physiology
explain vascular events and mechanisms of acute inflammation in detail
Inflammatory response is a mechanism that is used to protect from infection and injury.
Some complement components also promote inflammation by stimulating cells to release histamine and by attracting phagocytic cells to the site of infection.
Acute inflammation is characterized by vasodilatation, fluid exudation and neutrophil infiltration.
These processes are activated and amplified by intracellular and extracellular factors that tightly co-ordinate the inflammatory process. The innate immune system responds rapidly to infection or injury.
Inflammation involves three main stages:
Acute: swelling stage
Sub acute : regenerative stage
Chronic : scar tissue maturation and remodeling stage.
There are many events occured during acute inflammation.
Vasodilation: leads to greater blood flow to the area of inflammation, resulting in redness and heat.
Vascularpermeability: endothelial cells become leaky from either direct endothelial cell injury or via chemical mediators.
Exudation: fluid, proteins, red blood cells, and white blood cells escape from the intravascular space as a result of increased osmotic pressure extravascularly and increased hydrostatic pressure intravascularly.s
Vascularstasis: slowing of the blood in the bloodstream with vasodilation and fluid exudation to allow chemical mediators and inflammatory cells to collect and respond to the stimulus.