2. SWI/SNF is an important chromatin remodeler. a. What do chromatin remodelers do? b. How does...

2. SWI/SNF is an important chromatin remodeler.

a. What do chromatin remodelers do?

b. How does that have an effect on gene expression?

Expert Solution

The second type of chromatin modification that can influence genome expression is nucleosome remodeling.Two best studied classes of these complexs are the SWI/SNF family.

a.Answer: Remodeling in the strict sense,involve SWI/SNF a change in the structure of the nucleosome but not change in its position.In some cases,the remodeling can involve cis and trans displacement that involves movment of nucleosome.ATP-dependent chromatin remodeling complexes responsible for nucleoosome remdeling.

b Answer: Remodeling complex SWI/SNF is made up of >10 proteinsThe name derive from the catalytic ATPase subunit,which were first describes in mutants that were mating-type switching defective(Swi2) and sucrose nonfermenters (Snf2).In additionn to carrying TPase domains, it exhibits bromodomains which interact with acetylates lysine residue in histones.

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gladiator answered 2 years ago

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