What is dicoumarol? What is the role of this substance in the clotting process and what...

What is dicoumarol? What is the role of this substance in the clotting process and what are some examples of its toxicity?

Expert Solution

Dicoumarol is a derivative of naturally occurring coumarin. Dicoumarol depletes vitamin K by competitively inhibiting the enzyme Vitamin K epoxide reductase which is responsible for regulating the levels of vitamin K.The depletion of Vitamin K further cause depletion of the clotting proteins as vitamin K acts a co-factor for the enzymes that pos-translationally modify the clotting proteins by carboxylating the glutamic residues of these proteins- these clotting proteins are factors II, VII, IX and X.

Increased dosage leads to toxicity by causing uncontrolled hemorrhage. This is called sweet clover poisoning- this is becuase when the clover is spoiled, coumarol is converted to dicoumarol

gladiator answered 2 years ago

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