IL1RL1 is a gene which encodes a functional protein. The NCBI Accession can be found here....

IL1RL1 is a gene which encodes a functional protein. The NCBI Accession can be found here. https://www.ncbi.nlm.nih.gov/nuccore/NM_016232.5 If Alkylation damage were to occur at base 215 of this sequence, what would be the resulting change, and would that change the function of the protein and to what degree?

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Homo sapiens interleukin 1 receptor like 1 (IL1RL1), transcript variant 1, mRNA

human 1,997 bp mRNA sequence NM_016232.5.

it is a transcript sequence which will translate into protein . the protein means sequenced chain of amino acids. The sequence of aminoacids are totally dependent on the sequence of bases on m RNA. Any damage to any base may alter the amino acid sequence and would that change the structure and function of the protein .

If Alkylation damage were to occur at base 215 of this sequence:-

181 accaatactt gctcttgatt gataaacaga atggggtttt ggatcttagc aattctcaca 240

201 gataaacaga 210 211 atggggtttt 220

gggg :- sequence count 213 to 216 .

This means the 215 base is G. the alkylation damage of G :- Alkylation of guanine at the O6 atom is a highly mutagenic DNA lesion because it alters the coding specificity of the base causing G:C to A:T transversion mutations.

yes its mutagenic change in structure of protein a function of protein

gladiator answered 1 year ago

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