Does arsenate inhibit gluconeogenesis? (explain why or why not)

Expert Solution

Yes, arsenate inhibit gluconeogenesis.

Arsenate enters glyceraldehyde-3-phosphate instead of a P_i and when it happens, this can replace inorganic phosphate in the step of glycolysis. Then this product is spontaneously hydrolyzed producing 1,3-bisphosphoglycerate from glyceraldehyde 3-phosphate. 1-Arseno-3-phosphoglycerate is produced instead, which is unstable and is hydrolyzed to form the next intermediate in the pathway, 3-phosphoglycerate. and bypassing substrate level ATP generation. Therefore, glycolysis proceeds, but the ATPmolecule that is generated from 1,3-bisphosphoglycerate is completely lost. Arsenate is an uncoupler of glycolysis, account for the inhibition of gluconeogenesis.and explain its toxicity.

queen_honey_blossom answered 1 year ago

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