Does arsenate inhibit gluconeogenesis? (explain why or why not)

Expert Solution

Yes, arsenate inhibit gluconeogenesis.

Arsenate enters glyceraldehyde-3-phosphate instead of a P_i and when it happens, this can replace inorganic phosphate in the step of glycolysis. Then this product is spontaneously hydrolyzed producing 1,3-bisphosphoglycerate from glyceraldehyde 3-phosphate. 1-Arseno-3-phosphoglycerate is produced instead, which is unstable and is hydrolyzed to form the next intermediate in the pathway, 3-phosphoglycerate. and bypassing substrate level ATP generation. Therefore, glycolysis proceeds, but the ATPmolecule that is generated from 1,3-bisphosphoglycerate is completely lost. Arsenate is an uncoupler of glycolysis, account for the inhibition of gluconeogenesis.and explain its toxicity.

queen_honey_blossom answered 2 years ago

Why is arsenate toxic(way of action, enzyme)? And does arsenate inhibit gluconeogenesis? Explain why or why...

Why is arsenate toxic(way of action, enzyme)? And does arsenate inhibit gluconeogenesis? Explain why or why not.

What are some differences between the production of glycolysis and gluconeogenesis, and why does gluconeogenesis require...

What are some differences between the production of glycolysis and gluconeogenesis, and why does gluconeogenesis require a higher amount of ATP? Utilize examples and explain thoroughly the differences.

Why, according to the selectorate approach, does foreign aid inhibit democratization in recipient countries?

Why does acetylcholine excite skeletal muscle fibers but inhibit cardiac muscle fibers?

Why does rotenone inhibit oxidative phosphorylation when the substrate is pyruvate but not when it's succinate?

How does regulation of glycolysis and gluconeogenesis overlap?

1. If muscle-derived amino acids are used for gluconeogenesis, why does the rate of glucose output...

1. If muscle-derived amino acids are used for gluconeogenesis, why does the rate of glucose output by the liver slow during prolonged starvation?

1. How does lemon juice inhibit browning? (4 pts) 2. How does Fruit Fresh inhibit browning?...

1. How does lemon juice inhibit browning? (4 pts) 2. How does Fruit Fresh inhibit browning? (4 pts) 3. How does blanching inhibit browning? (4 pts) 4. How does the sugar solution inhibit browning? (4 pts) 5. What color is chlorophyll in acidic conditions? Basic conditions? (2 pts) 6. What color is anthocyanin in acidic conditions? Basic conditions? (2 pts)

Explain why poverty may inhibit economic growth. This is for an international economics course. The chapter...

Explain why poverty may inhibit economic growth. This is for an international economics course. The chapter is on poverty, inequality, and development.

1) Describe the function of each antibiotic. Does the antibiotic inhibit cell wall synthesis, inhibit protein...

1) Describe the function of each antibiotic. Does the antibiotic inhibit cell wall synthesis, inhibit protein synthesis, or something else? A) Penicillin B)Tetracycline C) Macrolide D) Cephalosporin E) Metronidazole F) Vancomycin G) Trimethoprim H)Chloramphenicol I)Rifampin

Question