Question

In: Anatomy and Physiology

human physiology Explain the function of Leydig cells and Sertoli cells in the development of sperm...

human physiology

Explain the function of Leydig cells and Sertoli cells in the development of sperm inside the testes.

Solutions

Expert Solution

Sertoli Cells

  • Sertoli cels extend from the basement membrane of germinal epithelium to the lumen of tubule.
  • Sertoli cells envelope developing germ cells.They support the developing spermatogenic cells.
  • They nourishes the sperm and help in spermatogenesis.
  • Phagocytosis of cytoplasm shed by developing spermatogenic cells
  • They are joined one another by junctional complexes and form the blood testis barrier.This barrier separate germinal epithelium into two compartment , a basal compartment which contain sertoli cells and diploid germ cell precursors and adluminal compartment , which contain the product of meosis.
  • It help in formation of androgen binding protein, antimullerian hormone etc..

Leydig Cell

  • Leydig cells are located within loose connective tissue surrounding seminiferous tubule.
  • Leydig cell produce testosterone , in response to leutinizing hormone released by pituitary gland .
  • Testosterone is responsible for secondary sexual characteristics and maintenance of germinal epithelium.
  • They also secrete androstenedione and dehydroepiandrosterone
  • They increase cholestrol desmolase activity, which help in conversion of cholestrol into pregnenolone

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