Question

Human Physiology

Describe the 28-day ovarian cycle (follicle phase & luteal phase), beginning with the development of primary follicles and ending with degeneration of the corpus luteum. Include in your description the role of granulosa cells, theca cells, and the zona pellucida.

Answer 1

Answer :

Ovulation cycle :

The menstrual cycle is a process that uninseminated human women go through about every 28 days. During this time, the women's ovaries create a mature ovum (egg). Then the woman's body prepares for pregnancy by thickening the walls of the uterus. If the woman does not become pregnant during this time, the egg and the lining of the uterus come out of the woman's body during menstruation.

The menstrual cycle process is controlled by four major hormones: FSH (follicle stimulating hormone); LH (luteinising hormone); estrogen; and progesterone. These hormones prepare the uterus to receive a fertilized egg and control its development.

The menstrual cycle has three stages: the Follicular stage, Ovulation, and the Luteal (or premenstrual) stage. The cycle will stop if the woman gets pregnant (if a fertilized egg implants itself into the lining of the uterus).

Follicular Stage:

This stage is the start of the menstrual cycle, and is counted as day one of the cycle. This stage starts when the amount of progesterone and estrogen in a woman's blood drop. This causes the endometrium - the thick lining of the uterus - to leave the woman's body through menstruation. It will appear as bleeding from the vagina. This stage lasts from 4–6 days.

At the start of this stage, the pituitary gland will begin to release more FSH. This will continue for 3-4 days. The FSH makes several follicles grow in one of the ovaries. Each follicle contains an immature ova (egg). These follicles create estrogen.

Usually, the amount of FSH in the body peaks during the third or fourth day of menstruation. All but one of the follicles dies off. The one that is left releases even more estrogen. Once again, the lining of the uterus thickens. Near the end of the stage, a woman's estrogen levels peak. This causes the pituitary gland to release LH, which also peaks at this time.

Ovulation:

Ovulation happens roughly every 14 days. This is when the mature egg is released into the oviduct(or fallopian tube) ready for fertilisation.

Ovulation happens if there is both a rise in estrogen and a peak in LH at the end of the follicular stage. The rising levels of LH make the ovum mature. The follicle that contains the ovum swells and breaks open. (In the next stage, the leftover cells of the follicle turn into an important structure called the corpus luteum.) The ovum is released into the Fallopian tube.

During ovulation, a woman's body temperature is usually about 0.5 degrees Celsius over normal.

Luteal Stage :

The follicle cells that used to hold the ovum now release progesterone into the body. This causes the endometrium to get even thicker.

If an ovum is going to be fertilized, it happens during this step. A woman becomes pregnant when a man's sperm fertilizes one of her ova, which then plants itself into the lining of the uterus.

If fertilized:

If the ovum is fertilized during Ovulation, it will become a zygote. It will start to copy itself over and over again through mitosis. It will also move from the ovarian duct into the uterus. The levels of estrogen and progesterone in the body remain high. The zygote grows into an embryo and implants itself into the endometrium tissue of the uterus. This forms a placenta, which starts to mature.