How is LIPOGENESIS in adipose tissue regulated after eating a meal rich in FATTY ACIDS? (how...

How is LIPOGENESIS in adipose tissue regulated after eating a meal rich in FATTY ACIDS? (how does insulin, various substrate availability affect this)

Expert Solution

Solution: Lipogenesis is a metaolic process through which Acetyl CoA is converted to storage form of triglycerides or fatty acids. Feeding a fatty acid rich meal abolishes the lipogenesis. Fasting for a long duration and feeding a fatty acid rich meal equally abolishes the conversion of acetyl CoA into triglycerides. Lipogenesis is reported to increase when high carbohydrate and fat free diet are provided.

During lipogenesis, acetyl coA is synthesized from citrate using the enzyme citrate lyase, which is an ATP dependent enzyme. This acetyl coA is then converted through sequence of steps to synthesize Triacylglycerol. Hormone insulin induces the production phosphofructokinase 2 enzyme that converts fructose 6 phosphate into fructose 2,6 bisphosphate which inturn induces the glycolytic pathway by converting fructose 6 phosphate to fructose 1,6 bisphosphate.

gladiator answered 2 years ago

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