Explain process of coagulation in detail?

Expert Solution

Ans:-

Coagulation:- Coagulation is also known as clotting. It is the process by which blood changes from liquid to a gel , forming a blood clot .

The mechanism of coagulation involves activation, adhesion and aggression of platelets , as well as deposition and maturation of fibrin .

Process of coagulation is as follows:-

It has three basic steps:-

1. Vasocontriction,

2. Platelet plug formation,

3. Coagulation.

1) vasocontriction :- In this stage constriction of blood vessel occurs to decrease blood flow after injury. Vessels contract in response to damage as well as substance released from activated platelets.

2) Formation of a platelet plug :- In this stage platelets clump together and adhere to the injured blood vessel to form a platelet plug.

3) Coagulation:- It involves a complex cascade in which a fibrin mesh is cleaved from fibrinogen. Fibrin acts as a molecular glue during clot formation holding the platelets plug together.

- Fibrinolysis :- In this stage clot dissolves when blood flow stops .

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