Question

Why do we care about the study of Sem-5 gene acting in sex myoblast cell Migration in C elegans?

Answer 1

C elegans is a transparent nematode lives in soil. Sem 5 gene or the sexual muscle abnormal protein 5 is an adaptor molecule. They modulate siganal mediated by several receptor tyrosine kinase such as let23 and EGL17. It negatively regulates the fluid homeostasis band involves in the sex myoblast migration.EGL-17, a fibroblast growth factor-like protein, is expressed in the
gonadal cells required to attract the sex myoblasts to their precise final positions, further supporting our model that EGL-17
defines the gonad-dependent attractant. Furthermore, cell ablation experiments reveal that EGL-17 and the gonad dependent repellent likely emanate from the same cellular sources. Analyses of candidate mutations for their effects on the
gonad-dependent repulsion reveal that a set of genes known to affect multiple aspects of axonogenesis, unc-14, unc-33,
unc-44, and unc-51, is essential for this repulsive mechanism