Question

what's the peptide pathway of the Neuropeptide y (NPY) and design a theoretical drug that activates the same receptors of that peptide

Answer 1

Neuropeptide Y (NPY) is a neuropeptide of 36 amino acids involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY was described as the most abundant peptide present in the central nervous system of mammals, which consists of the brain and spinal cord.

Neuropeptide Y act as a neurotransmitter in the brain and ANS.

In the central and peripheral nervous systems, neuropeptide Y (NPY) is synthesized and secreted by pancreatic cells in response to neuron impulses. It inhibits insulin secretion stimulated by glucose, and is present in the digestive tract in the myenteric and submucosal nerve plexuses.

NPY mediates its effects by activating six subtypes of G-protein - coupled receptors I.e. Y(1), Y(2), Y(3), Y(4), Y(5), and y. NPY is involved in the pathophysiology of many disorders, such as food intake control, metabolic disorders , anxiety, epilepsy, memory, circadian rhythm, drug addiction, pain, cardiovascular disease, rhinitis, and endothelial cell disease.

Design a theoretical drug that activates neuropeptide y receptors of the peptide?

Receptor are Y1R Y2R Y4R Y5R

pro-neuropeptide y drug

Or obesity drugs

Neuropeptide y is a protein made of 36 amino acids which bind to Y1R,Y2R,Y4R,Y5R receptors only so pro-neuropeptide y drugs are given so that the drug pharmaceutical value and work on the place were it is needed.