In: Biology
Why is it important that the initiation of DNA replication is carefully regulated? What is the proposed role of DnaA in this process?
What extra proteins are necessary for lagging-strand synthesis that are not needed in leading-strand synthesis?
Replication in eukaryotes is similar to that of prokaryotes. However initiation is different. Describe how initiation of replication occurs and how it is tied to the cell cycle.
Explain in general terms how DNA replication can occur in a chromatin environment and how epigenetic marks associated with chromatin are conserved during replication.