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8. Drug molecules moving between “compartments” move at different equilibrium constants. There are many factors that...

8. Drug molecules moving between “compartments” move at different equilibrium constants. There are many factors that affect the rate at which drug molecules move: name three of these factors & explain in 1 sentence each why it would affect distribution.

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Expert Solution

The drug molecules move between compartments - plasma, interstitial fluid, intracellular fluid and transcellular fluid. There are many factors that may affect the rate of distribution between these compartments that could be either drug related or related to the host's body. Three of the factors related to the host are as below:

  • Vascularity - Most of the organs in the body have abundant blood flow, whereas some have relatively lower blood flow. Drugs reach the organs that has copious blood supply first and then they get redistributed to the organs with lower supply. Sometimes drugs may be prevented from reaching the organs with lower blood supply.
  • Transport mechanism - Different compartments of the body transport different types of drugs. For example - Passive transport occurs only in the case of lipid soluble drugs but active transport occurs only where carrier proteins are present.
  • Blood Barriers - Blood barriers such as Blood Brain Barrier (BBB) do not allow drugs to reach the brain. Only few drugs such penecillin can pass through the BBB, when it is disrupted due to meningitis.

gladiator answered 1 year ago
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