8. Drug molecules moving between “compartments” move at different equilibrium constants. There are many factors that...

8. Drug molecules moving between “compartments” move at different equilibrium constants. There are many factors that affect the rate at which drug molecules move: name three of these factors & explain in 1 sentence each why it would affect distribution.

Solutions

Expert Solution

The drug molecules move between compartments - plasma, interstitial fluid, intracellular fluid and transcellular fluid. There are many factors that may affect the rate of distribution between these compartments that could be either drug related or related to the host's body. Three of the factors related to the host are as below:

Vascularity - Most of the organs in the body have abundant blood flow, whereas some have relatively lower blood flow. Drugs reach the organs that has copious blood supply first and then they get redistributed to the organs with lower supply. Sometimes drugs may be prevented from reaching the organs with lower blood supply.
Transport mechanism - Different compartments of the body transport different types of drugs. For example - Passive transport occurs only in the case of lipid soluble drugs but active transport occurs only where carrier proteins are present.
Blood Barriers - Blood barriers such as Blood Brain Barrier (BBB) do not allow drugs to reach the brain. Only few drugs such penecillin can pass through the BBB, when it is disrupted due to meningitis.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate...

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.78×10−6 M . Drug A is introduced into the protein solution at an initial concentration of 2.00×10−6M. Drug B is introduced into a separate, identical protein solution at an initial concentration...

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate...

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.66×10−6 M . Drug A is introduced into the protein solution at an initial concentration of 2.00×10−6M. Drug B is introduced into a separate, identical protein solution at an initial concentration...

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate...

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.76×10−6 M . Drug A is introduced into the protein solution at an initial concentration of 2.00×10−6M. Drug B is introduced into a separate, identical protein solution at an initial concentration...

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate...

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.58×10−6 M . Drug A is introduced into the protein solution at an initial concentration of 2.00×10-6 M. Drug B is introduced into a separate, identical protein solution at an initial...

8. When fossil fuel is burned, many different types of carbon-based molecules can be emitted. Of...

8. When fossil fuel is burned, many different types of carbon-based molecules can be emitted. Of all carbon-based emissions, carbon dioxide is the best-case scenario given what will occur to the other carbon-based emissions. Explain why you agree or disagree with the previous statement and the consequence of this fact. (SHORT ESSAY)

What are some ways to weaken the forces between the drug molecules in their solid state...

What are some ways to weaken the forces between the drug molecules in their solid state to increase their solubility in water?

1.Many factors affect drug absorption. Select five (5) of these factors and provide a rationale or...

1.Many factors affect drug absorption. Select five (5) of these factors and provide a rationale or mechanism(s) for each one’s effects on drug absorption. Use examples to clarify your answer.

1. Many different molecules need to pass in and out of a cell across the cell...

1. Many different molecules need to pass in and out of a cell across the cell membrane and from the outside of the body to the inside. Some of these molecules are hydrophobic and some are hydrophilic. Define these two terms and explain why they differ in their ability to pass through cell membranes. What part of a cell membrane makes it so tricky for some molecules to get through? How do these two types of molecules pass through cell...

The decision to use a particular drug formulation is based on many factors, including onset of...

The decision to use a particular drug formulation is based on many factors, including onset of action, physician/patient preferences, and the available routes of administration. Describe one to two instances where an injectable route of administration might be preferred over an oral route. Identify the advantages to using an injectable route in those scenarios.

There are many factors in the drug laws that influence addiction. Use the information you gained...

There are many factors in the drug laws that influence addiction. Use the information you gained in life and DISCUSS 4 different insights.

Subjects