Describe the role of voltage gated sodium channels in action potentials that travel along the sarcolemma.

Expert Solution

Action potentials result from the depolarization of the cell membrane (the sarcolemma), which opens voltage-sensitive sodium channels. These become inactivated and the membrane is repolarized through the outward current of potassium ions. Production of an end plate potential at the motor end plate causes adjacent areas of the sarcolemma to become permeable to sodium (voltage-gated sodium channels open). As sodium ions diffuses rapidly into the cell, the resting potential is decreased, i.e. depolarization occurs. If the stimulus is strong enough, n action potential is initiated.

The positive charge inside the initial patch of sarcolemma changes the permeability of an adjacent patch, opening voltage-gated sodium channels there. As a result the membrane potential in that region decreases and depolarization occurs, thus the action potential travels rapidly over the sarcolemma. After this depolarization wave passes, the sarcolemma’s permeability changes once again.

gladiator answered 1 year ago

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