Eicosanoids are paracrine hormones that have a variety of dramatic effects on vertebrate tissues. There are...

Eicosanoids are paracrine hormones that have a variety of dramatic effects on vertebrate tissues. There are three classes of eicosanoids. Define each of these classes and elaborate on their functions. What are NSAIDs and what is the basis behind NSAIDs function?

Three classes of eicosanoids: prostaglandins, thromboxanes, and leukotrienes.

Expert Solution

Eicosanoids are 20 C compounds derived from Arachidonic acid.

1. Prostaglandins: Present in almost all tissues. Most potent biological active substances because at very low concentration, it cause smooth muscle contraction. Prostacyclinn(PGI2) has a major effect of vasodilation and inhibit platelets aggregation.

2. Thromboxanes: It is produced by platelets. Its main effect is vasoconstriction and platelets aggregation.

3. Leukotrienes: Most potent chemotactic agent (factor attracting cells to the inflammatory cells). The slow reacting substance of anaphylaxis ( SRS- A) contains LTC4, LTD4 ,etc. It cause smooth muscle contraction,bronchioles contraction, increases capillary permeability, activate leucocytes and produce vasoconstriction. Leukotrienes has major role in asthma.

gladiator answered 2 years ago

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