Question

I have a research about the "Nano-wafers", and i need to write an outline and some points that i can address in my paper

Answer 1

A nanowafer is a small transparent circular disc containing arrays of drug loaded nanoreservoirs to be applied on the ocular surface. The drug is released in a controlled fashion, for a few hours to several days. The slow release ensures longer retention and improved penetration of drug, resulting in improved absorption and patient compliance.

Example: Axitinib nanowafers prepared using PVA were found to be nonimmunogenic with the bioavailability of once a day nanowafer, being twice that of topical eye drops administered twice daily.

These nanowafers are thinner than contact lenses and dissolve upon contact with the ocular surface at a predetermined rate (30 minutes to 7 days), hence they are relatively well tolerated.

Nanowafers made from carboxymethylcellulose have also shown good tolerability in mouse eyes and therapeutic concentrations of dexamethasone could be achieved at significantly lower doses.

Corneal wound healing and inflammation suppression observed with the nanowafers was comparable to conventional dexamethasone eye drops, even at a four fold lower drug concentration and alternate day dosing frequency, demonstarting the excellent potential of this technology.

Refrences:

1. Acharya, G., Pflugfelder, S.C., Cintia, P.S., Aimpson, J.L. Therapeutic dispensing device and methods of making same United States patent application. (2012)

2. Yuan, X., et al. Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS Nano. 9: 1749-1758 (2015)