Mrs. Jones has a serious case of conjunctivitis and the doctor orders chloramphenicol and penicllin. Why...

Mrs. Jones has a serious case of conjunctivitis and the doctor orders chloramphenicol and penicllin. Why would the administration of both of these antibiotics be contraindicated? Explain in detail why.

Expert Solution

Answer:- It is a well known fact that administration of bacteriostatic antibiotics (antibiotic that stops bacteria from reproducing ) in combination with bactericidal antibiotics (antibiotics that kill bacteria) will result in antagonism and reduced efficiency of the treatment. In this case also, chloramphenicol being the bacteriostatic antibiotic will interact and antagonise the effect of penicillin which is a bactericidal antibiotic. Various research articles have been published which have proven that administration of bacteriostatic and bactericidal antibiotics together will result in antagonism. The reason for this is that bactericidal antibiotics are most potent on the actively growing bacteria and kill them easily thus the inhibition of growth with bacteriostatic antibiotic would result in reduced efficiency of the bactericidal antibiotic as there will not be enough activily growing bacteria present. This may even result in development of resistance in bacteria towards the antibiotics used. Therefore it is not advisable to use bactericidal and bacteriostatic antibiotics in a combination to treat bacterial infections.

gladiator answered 1 year ago

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