The mitochondrial inner membrane is impermeable to CoA and acylCoA. However, β-oxidation occurs in the mitochondrial matrix.

The mitochondrial inner membrane is impermeable to CoA and acylCoA. However, β-oxidation occurs in the mitochondrial matrix. AcylCoA is formed in the ________, and the acyl group is transferred to ______, which can cross the inner membrane through a translocase, and the acylCoA is regenerated in the _________.

Expert Solution

Matrix of mitochondria,

Citrate,

Cytosol.

Acetyl coA forms in the matrix of mitochondria. It cannot cross the inner mitochondrial membrane. So it passes it's acetyl group to citrate. Citrate leaves mitochondria and enters cytosol. In cytosol citrate reacts with cytosolic coA and ATP to form acetyl coA.

gladiator answered 2 years ago

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