Members of the epidermal growth factor receptor tyrosine kinase (RTK) family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4)...

Members of the epidermal growth factor receptor tyrosine kinase (RTK) family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy. Critical for activation is the formation of a dimer in the cytoplasmic domain that induces autophosphorylation on specific tyrosine residues. A cytoplasmic protein, called MIG6, interacts with the cytoplasmic domains of RTKs and inhibits their kinase domain. Based on your knowledge of RTK signaling, what effect would you expect MIG6 overexpression in cancer cells to have on

a) Ras activation,

b) PI3-kinase activation

c) MAP kinase translocation into the nucleus

For each question briefly explain your answer.

Expert Solution

gladiator answered 2 years ago

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