Members of the epidermal growth factor receptor tyrosine kinase (RTK) family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4)...

Members of the epidermal growth factor receptor tyrosine kinase (RTK) family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy. Critical for activation is the formation of a dimer in the cytoplasmic domain that induces autophosphorylation on specific tyrosine residues. A cytoplasmic protein, called MIG6, interacts with the cytoplasmic domains of RTKs and inhibits their kinase domain. Based on your knowledge of RTK signaling, what effect would you expect MIG6 overexpression in cancer cells to have on

a) Ras activation,

b) PI3-kinase activation

c) MAP kinase translocation into the nucleus

For each question briefly explain your answer.

Expert Solution

gladiator answered 1 year ago

A receptor tyrosine kinase (RTK) has a non-functioning kinase domain

A receptor tyrosine kinase (RTK) has a non-functioning kinase domain Enhanced or Reduced A G-protein whose α-subunit has a higher than normal binding affinity for GTP and a normal binding affinity for GDP. Enhanced or Reduced Protein Kinase A whose regulatory subunits cannot bind cAMP Enhanced or Reduced IP3 cannot bind to ER-calcium channels Enhanced or Reduced Notch cannot be cleaved following binding to Delta Enhanced or Reduced Sodium orthovanadate, a phosphatase inhibitor, is added to cells that have...

Q. Draw a map of how the Receptor Tyrosine Kinase (RTK) links to the Ras-Map Kinase...

Q. Draw a map of how the Receptor Tyrosine Kinase (RTK) links to the Ras-Map Kinase Pathway versus the PI3K/AKT Pathway. Be sure to include where these pathways end up - the cellular response. Keep in mind that Ras-Map and PI3K/AKT are at the top of the pathway. I want you to pick a direction coming down. Your textbook can help get you started, but you will have to research/Google where these pathways go. While there are many possible directions,...

What is a tyrosine kinase receptor (RTK)? Describe how this type of receptor works. Once activated,...

What is a tyrosine kinase receptor (RTK)? Describe how this type of receptor works. Once activated, what kind of enzyme is needed to deactivate the receptor? Explain

Why would overexpression of RTK (Receptor Tyrosine Kinase) lead to an oncogenic phenotype (describe the mechanism)?

Give one example of how you would assay for overexpression of RTK (Receptor Tyrosine Kinase). Would...

Give one example of how you would assay for overexpression of RTK (Receptor Tyrosine Kinase). Would it be an immune complex kinase assay then determine if it's a tyrosine kinase? I'm not sure.

1. The insulin receptor is: A. a metabolite receptor B. a receptor tyrosine kinase. C. a...

1. The insulin receptor is: A. a metabolite receptor B. a receptor tyrosine kinase. C. a GPCR D. a gasotransmitter E. a second messenger 2. Which of the following reactions requires a Vitamin B12 cofactor? A. beta-oxidation of 18:0 B. beta-oxidation of (18:1 delta 9) C. beta-oxidation of (16:2 delta 9 delta 12) D. complete oxidation of (19:0) E. all of these require Vitamin B12 3. Metabolite receptors bind to ___________________. A. second messengers B. DNA C. GPCRs D. Protein...

Binding of a signal to the receptor tyrosine kinase DIRECTLY, initially causes:

Describe the series of events that occurs when a ligand binds to a receptor tyrosine kinase...

Describe the series of events that occurs when a ligand binds to a receptor tyrosine kinase during cellular signalling, and what occurs once the ligand is removed? Describe the series of events that occurs before and after a ligand binds to a G protein coupled receptor during cellular signalling?

Why does signaling through a peptide growth factor (such as Epidermal Growth Factor) allow for more...

Why does signaling through a peptide growth factor (such as Epidermal Growth Factor) allow for more rapid responses in a cell than signaling through a steroid hormone such as estrogen?

Explain the cell signaling pathway which involves membrane receptor (tyrosine kinase receptors and G protein-coupled receptors)....

Explain the cell signaling pathway which involves membrane receptor (tyrosine kinase receptors and G protein-coupled receptors). Use ONE (1) specific example to explain each reception pathway. The details of the summary should be concise and informative. The length of the summary for each type of membrane receptor should be less than 200 words.

Question