Question

1. If drug X has a half-life (T1/2) of 2 days (48 hours) and the concentration at 12:00 today was 10 μg/mL, what would the expected concentration of drug X be at 12:00 tomorrow?

a. 7 μg/mL

b. 7.5 μg/mL

c. 5 μg/mL

d. 3.5 μg/mL

2. If a drug is administered orally, which of the following would affect the efficiency of its absorption in the gastrointestinal tract?

a. Dissociation of the drug from its administered form

b. The drug's solubility in gastrointestinal fluid

c. Diffusion of the drug across gastrointestinal membranes

d. All of the above

3. If a trough specimen is required for therapeutic drug monitoring, the most appropriate time to collect the specimen would be:

a. Eight hours after the last dose was given

b. Three days after the dose was administered

c. Immediately after the dose is administered

d. Immediately before the next dose is given

4. Which of the following statements concerning procainamide is TRUE?

a. Procainamide should be administered intravenously due to poor absorption.

b. Procainamide is an antibiotic used to treat gram-positive bacterial infections.

c. Procainamide is metabolized into an active metabolite with similar antiarrhythmic activity.

d. Procainamide is eliminated entirely through renal filtration.

5. Which of the following statements concerning lithium is TRUE?

a. Lithium is used to treat depression, self-mutilating behavior, and bipolar disorder.

b. Lithium toxicity has been associated with ototoxicity and nephrotoxicity.

c. Lithium is completely metabolized in the liver with no renal elimination.

d. Lithium is used in conjunction with cyclosporine to prevent transplant rejection.

6. Which of the following is the primary purpose for measuring serum concentrations of methotrexate?

a. To determine the optimum dosage for oral administration of methotrexate

b. To ensure that serum concentrations are within the therapeutic range

c. To confirm serum concentrations when toxicity is suspected

d. To determine the amount of leucovorin needed to halt methotrexate action

7. Primidone is an inactive preform of which of the following antiepileptic drugs?

a. Gabapentin

b. Clozapine

c. Phenobarbital

d. Ethosuximide

8. Bilirubin competes with some drugs for the same binding site on plasma proteins. What effect would an increased concentration of bilirubin in the blood (bilirubinemia) have on the potential activity of this drug?

a. The fraction of bound drug would increase thereby increasing potential activity.

b. The fraction of bound drug would decrease thereby decreasing potential activity.

c. The fraction of bound drug would decrease thereby increasing potential activity.

d. The fraction of bound drug would increase thereby decreasing potential activity.

9. Twenty milligrams (mg) of drug Y is injected intravenously. One hour after the injection, blood is collected and assayed for the concentration of drug Y. If the concentration of drug Y in this specimen was 0.4 mg/L, what is the volume of distribution for this drug?

a. 0.8 L

b. 8 L

c. 20 L

d. 50 L

No Explanation needed

Answer 1