Distribution, Metabolism, Drug Interactions, and the
Effects of Aging, Obesity, and
Disease
Problem #4
Please describe 3 different processes through which a drug can
exert pharmacokinetic non-linearity and give an example of a drug
(different drug for each type) that exerts this type of
non-linearity for each example (e.g., saturablemetabolism and
phenytoin)
Absorption-related non-linearity – mechanism and example of a
drug
Distribution-related non-linearity – mechanism and example of a
drug
Metabolism-related non-linearity – mechanism and example of a
drug
Problem...